Uneven skin tone can be caused by a number of different factors including sun damage, certain medications, hormonal changes, and certain skin conditions. There are a number of different treatments that can help improve uneven skin tone including over-the-counter lightening agents, prescription topical creams or oral medications, laser therapy, and chemical peels. You can help prevent uneven skin tone by taking measures to protect your skin from sun damage and avoiding triggers that can worsen existing skin conditions.